| DOMAIN ASSOCIATES |
| 10 percent owner |
| D-Return |
| Disposed |
| 47,963 |
| $1.52 |
| 13 Dec 2017 | DP VI Associates, L.P. | 10 percent owner | D-Return | Disposed | 15,731 | $1.52 |
| 11 Dec 2017 | Bukofzer Stan | Chief Medical Officer | D-Return | Disposed | 200,000 | $1.52 |
| 11 Dec 2017 | Bukofzer Stan | Chief Medical Officer | D-Return | Disposed | 300,000 | $3.06 |
| 11 Dec 2017 | Bukofzer Stan | Chief Medical Officer | D-Return | Disposed | 208,350 | $2.15 |
| 11 Dec 2017 | WEBER ECKARD | director | D-Return | Disposed | 10,000 | $7.84 |